The two groups were comparable with respect to age, ASA class, sex, weight, basal vital signs, operation time. Results were analyzed by SPSS version 11.5. The hemodynamic variability, recovery profile, postoperative nausea and vomiting (PONV), surgeons satisfaction were assessed. Group MCI received propofol and remifentanil by conventional-dose-weight infusion method, and Group TCI received propofol 4 microg/ml and remifentanil 4 ng/ml as effect-site target concentration. Sixty patients, aged 18-60 years ASA I-II enrolled in the study, were divided into two equal groups. Our aim in this study was to assess the anesthesia profile of the propofol and remifentanil target controlled infusion (TCI) anesthesia as compared to the manually controlled infusion (MCI), in mastoidectomy surgery, where a bloodless field is of utmost importance to the surgeon. The performance of propofol TCI delivery when combined with remifentanil in patients undergoing elective surgeries has been investigated. Target-controlled infusion (TCI) system is increasingly used in anesthesia to control the concentration of selected drugs in the plasma or at the site of drug effect (effect-site).
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